Bioinformatics

Bioinformatics

 

Jan Peter Nap

Jan Peter Nap, cluster leader

 

Bioinformatics relates to the in silico storage, manipulation, analysis and mining of large omics datasets. It is at the cross-roads between molecular biology, computer science and mathematics and is hugely important in converting (abstract) quantitative data into biologically-relevant knowledge.

 

CBSG has access to the full gamut of genomics technology platforms – covering all molecular levels from DNA, RNA, protein and metabolite. Furthermore, CBSG scientists generate large amounts of phenotypic information on quantitative / qualitative quality aspects, morphology, yield parameters, gene function data etc. This diversity of data and the size of the datasets produced require dedicated state-of-the-art approaches towards data management and mining. The CBSG Bioinformatics programme aims not only to facilitate this but also will enable us to go beyond this and join all these pieces of information together to see even more of the picture behind the puzzle.

Bioinformatics

Ffrom data to information to knowledge

The CBSG Bioinformatic programme are carried out in association with the Netherlands Bioinformatics Centre (NBIC). Key topics include:

  • Database design and management
  • Implementation / exploitation of next generation sequencing platforms
  • Bioinformatics for qualtitative proteomics and metabolomics
  • Advanced linkage / linkage disequilibrium mapping
  • Genetical genomics
  • Modelling genotype-phenotype associations
  • Gene discovery / gene function prediction platforms